Polypyrrole Nanosheets Prepared by Rapid In Situ Polymerization for NIR-II Photoacoustic-Guided Photothermal Tumor Therapy

Recently, the near-infrared-II (NIR-II, 1000–1350 nm) region has been extensively applied in deep-tissue photothermal therapy (PTT) on account of it having stronger tissue penetration and a higher maximum permissible exposure (MPE) than near-infrared-I (NIR-I, 650–950 region. In this study, we developed rapid convenient situ polymerization strategy to fabricate polypyrrole nanosheets (PPy NSs) within few minutes using manganese dioxide (MnO2 as both oxidant self-sacrificed template. The fabricated PPy NSs exhibited excellent NIR-II absorption, which conferred its high conversion efficiency (66.01%) at 1064 nm photoacoustic (PA) imaging capability. Both vivo vitro studies have shown that possess good biological safety PTT efficacy PA performances. Thus, as-synthesized could effectively achieve imaging-guided tumor ablation under excitation. Our work provides novel promising method for preparation without addition exogenous oxidants subsequent template removal, be regarded potential agents (PTAs) integrate diagnosis treatment cancer.